Prenoxad: Naloxone Injection Kit

Prenoxad is a naloxone hydrochloride injection used to reverse opioid overdose, including respiratory depression caused by natural and synthetic opioids. It's a competitive antagonist of μ, δ, and κ-opioid receptors, with the highest potency at μ-receptors. ¹ ² ³

Key Uses:

- _Emergency Treatment_: Reverses opioid overdose, including respiratory depression

- _Diagnosis_: Helps diagnose suspected acute opioid overdose

- _Post-Surgical Care_: Reverses opioid-induced respiratory depression after surgery

Administration:

- Given via intramuscular (IM) injection, typically in the thigh or upper arm

- Dose: 0.4 mg to 2 mg, repeatable every 2-3 minutes if needed

Important Notes:

- Works within 2-5 minutes, lasting 30-90 minutes

- May cause withdrawal symptoms in opioid-dependent individuals

- Not a substitute for emergency medical care; call 000 after administration

- Available in pre-filled syringes (1mg/mL, 2mL) ⁴

Side Effects:

- Common: Dry mouth, blurred vision, constipation, urinary retention

- Serious: Confusion, hallucinations, seizures, coma (rare)

Contraindications:

- Known hypersensitivity to naloxone or other ingredients

- Use with caution in patients with heart problems or pregnant/breastfeeding women