Orladeyo (berotralstat)

It's a once-daily oral capsule that works by blocking the action of kallikrein, a protein that triggers the release of bradykinin, which causes blood vessels to leak and lead to swelling and inflammation.

How it Works

Orladeyo targets and blocks kallikrein activity, reducing bradykinin levels in the body, which helps prevent fluid leakage into tissues and reduces swelling and inflammation associated with HAE attacks.

Common Side Effects

Some common side effects of Orladeyo include:

- Abdominal pain

- Vomiting

- Diarrhea

- Back pain

- Heartburn

- Headache

Important Safety Information

- Orladeyo is not approved for treating acute HAE attacks.

- Do not take more than one capsule per day, as it may cause heart rhythm problems.

- Inform your healthcare provider about all medications, including HAE treatments, prescription and over-the-counter medicines, vitamins, and herbal supplements