Tecentriq (Atezolizumab)
Tecentriq (atezolizumab) is a programmed death-ligand 1 (PD-L1) blocking antibody indicated for the treatment of patients with:
locally advanced or metastatic urothelial carcinoma who have either; disease progression during or following platinum-containing chemotherapy, or within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy[1] or are not eligible for cisplatin chemotherapy[4].
metastatic non-small cell lung cancer (NSCLC) whose disease progressed during or following platinum-containing chemotherapy[1,5].
plus nab-paclitaxel (chemotherapy) for unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose tumours have PD-L1 expression[10].
How does Tecentriq (atezolizumab) work?
Tecentriq (atezolizumab) belongs to a class of immunotherapy drugs known as checkpoint inhibitors.
The drug prevents a protein called PD-L1 that is found on some tumour cells from binding to another protein, PD-1, on immune cells. The binding of these “checkpoint” proteins suppresses the immune response[2]. Tecentriq (atezolizumab) is a monoclonal antibody that binds to PD-L1 and blocks its interactions with both PD-1 and B7.1 receptors[1]. By blocking this interaction, checkpoint inhibitors “release the brakes” on the immune system, allowing immune cells to attack tumours[2].
Is Tecentriq (atezolizumab) approved?
Tecentriq (atezolizumab) was approved by:
Food and Drugs Administration (FDA) (USA)
on May 18, 2016, for locally advanced or metastatic urothelial carcinoma, with disease progression on or after prior chemotherapy[2]. On April 17, 2017, the FDA extended the approval to the use of Tecentriq (atezolizumab) as front-line treatment for advanced or metastatic urothelial carcinoma in patients who are not eligible for cisplatin chemotherapy[4].
on October 18, 2016, for metastatic non-small cell lung cancer (NSCLC)[3].
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Tecentriq (Atezolizumab)
This medicine requires a prescription. See “Prescription Guide”.
We can only help if the medicine is not available in your country. Learn more.
Price Frequently Asked Questions Details Patient stories Import guides
Tecentriq (atezolizumab) is a medication used for the treatment of locally advanced or metastatic urothelial carcinoma, for the treatment of metastatic non-small cell lung cancer (NSCLC), and for the treatment of advanced triple negative breast cancer (TNBC).
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Tecentriq
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Disease Indications
Urothelial Carcinoma, Breast Cancer, Lung Cancer
Manufacturer
Roche Registration Limited
Usage
Intravenous
Medicine approved by
European Medical Agency (EMA)
Food and Drug Administration (FDA)
Health Canada
Pharmaceuticals and Medical Devices Agency (PMDA)
Therapeutic Goods Administration (TGA)
Medsafe (NZ)
Patients helped
Over 1.2 million patients reached
More than 11,000 patients helped
100% successful deliveries to 88 countries
We can help with your import documents
We are experts in import regulations. Scroll below to download the import guide for your country.
Tecentriq (atezolizumab)
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FAQ
What is Tecentriq (atezolizumab) for?
Tecentriq (atezolizumab) is a programmed death-ligand 1 (PD-L1) blocking antibody indicated for the treatment of patients with:
locally advanced or metastatic urothelial carcinoma who have either; disease progression during or following platinum-containing chemotherapy, or within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy[1] or are not eligible for cisplatin chemotherapy[4].
metastatic non-small cell lung cancer (NSCLC) whose disease progressed during or following platinum-containing chemotherapy[1,5].
plus nab-paclitaxel (chemotherapy) for unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose tumours have PD-L1 expression[10].
How does Tecentriq (atezolizumab) work?
Tecentriq (atezolizumab) belongs to a class of immunotherapy drugs known as checkpoint inhibitors.
The drug prevents a protein called PD-L1 that is found on some tumour cells from binding to another protein, PD-1, on immune cells. The binding of these “checkpoint” proteins suppresses the immune response[2]. Tecentriq (atezolizumab) is a monoclonal antibody that binds to PD-L1 and blocks its interactions with both PD-1 and B7.1 receptors[1]. By blocking this interaction, checkpoint inhibitors “release the brakes” on the immune system, allowing immune cells to attack tumours[2].
Is Tecentriq (atezolizumab) approved?
Tecentriq (atezolizumab) was approved by:
Food and Drugs Administration (FDA) (USA)
on May 18, 2016, for locally advanced or metastatic urothelial carcinoma, with disease progression on or after prior chemotherapy[2]. On April 17, 2017, the FDA extended the approval to the use of Tecentriq (atezolizumab) as front-line treatment for advanced or metastatic urothelial carcinoma in patients who are not eligible for cisplatin chemotherapy[4].
on October 18, 2016, for metastatic non-small cell lung cancer (NSCLC)[3].
Health Canada on April 12, 2017
for locally advanced or metastatic urothelial carcinoma, with disease progression on or after prior chemotherapy[8].
for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC) in combination with carboplatin and etoposide[8].
for the first-line treatment of adult patients with metastatic non-squamous non-small cell lung cancer (NSCLC) in combination with bevacizumab, paclitaxel and carboplatin[8].
for adult patients with locally advanced or metastatic NSCLC with progression on or after platinum-based chemotherapy[8].
Therapeutic Goods Administration (TGA) (AUS)
on July 27, 2017, for metastatic non-small cell lung cancer (NSCLC)[5].
European Medicines Agency (EMA) (EU)
on September 22, 2017, for locally advanced or metastatic non-small cell cancer (NSCLC) and metastatic urothelial carcinoma (mUC) on patients who have been previously treated with a platinum-based chemotherapy and as front-line treatment for advanced or metastatic urothelial carcinoma in patients who are not eligible for cisplatin chemotherapy[6].
on August 29, 2019, in combination with nab-paclitaxel for advanced TNBC in patients who have not been previously treated with chemotherapy for metastatic disease[10].
Medsafe on February 14, 2019
for first-line treatment of patients with metastatic non-squamous NSCLC who do not have tumour EGFR or ALK genomic aberrations[9].
for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy[9].
for the first-line treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC)[9].
for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma[9].
How do I take Tecentriq (atezolizumab)?
Complete information about Tecentriq (atezolizumab) dosage and administration can be found in the references section[1,5,7].
The recommended therapy consists of:
- 1200 mg as an intravenous infusion over 60 minutes every 3 weeks.
- Dilute prior to intravenous infusion.
Complete information about Tecentriq (atezolizumab) dosage and administration can be found in the references section.
Consult your treating doctor for personalised dosing.
Are there any known side effects of Tecentriq (atezolizumab)?
The most common side effects (≥ 20%) in patients with locally advanced or metastatic urothelial carcinoma were fatigue, decreased appetite, nausea, constipation, urinary tract infection, diarrhea, and fever. The most common adverse reactions (≥ 20%) in patients with metastatic non-small cell lung cancer were fatigue, decreased appetite, dyspnea, cough, nausea, musculoskeletal pain, and constipation[1].
For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information[1,5,7].
What are you looking for?
en
Menu
Medicines
Is this legal?
About us
Contact us
Resources
Healthcare Professionals & Pharmacies
Account
Tecentriq (Atezolizumab)
This medicine requires a prescription. See “Prescription Guide”.
We can only help if the medicine is not available in your country. Learn more.
Price Frequently Asked Questions Details Patient stories Import guides
Tecentriq (atezolizumab) is a medication used for the treatment of locally advanced or metastatic urothelial carcinoma, for the treatment of metastatic non-small cell lung cancer (NSCLC), and for the treatment of advanced triple negative breast cancer (TNBC).
Skip to the end of the images gallery
Tecentriq
Skip to the beginning of the images gallery
Disease Indications
Urothelial Carcinoma, Breast Cancer, Lung Cancer
Manufacturer
Roche Registration Limited
Usage
Intravenous
Medicine approved by
European Medical Agency (EMA)
Food and Drug Administration (FDA)
Health Canada
Pharmaceuticals and Medical Devices Agency (PMDA)
Therapeutic Goods Administration (TGA)
Medsafe (NZ)
Patients helped
Over 1.2 million patients reached
More than 11,000 patients helped
100% successful deliveries to 88 countries
We can help with your import documents
We are experts in import regulations. Scroll below to download the import guide for your country.
Tecentriq (atezolizumab)
Enquire
GDP compliant. View certificate.
Licensed wholesale distributor. View certificate.
Details
Clinical trials
Price & costs
Shipping
Our process
Approvals
FAQ
What is Tecentriq (atezolizumab) for?
Tecentriq (atezolizumab) is a programmed death-ligand 1 (PD-L1) blocking antibody indicated for the treatment of patients with:
locally advanced or metastatic urothelial carcinoma who have either; disease progression during or following platinum-containing chemotherapy, or within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy[1] or are not eligible for cisplatin chemotherapy[4].
metastatic non-small cell lung cancer (NSCLC) whose disease progressed during or following platinum-containing chemotherapy[1,5].
plus nab-paclitaxel (chemotherapy) for unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose tumours have PD-L1 expression[10].
How does Tecentriq (atezolizumab) work?
Tecentriq (atezolizumab) belongs to a class of immunotherapy drugs known as checkpoint inhibitors.
The drug prevents a protein called PD-L1 that is found on some tumour cells from binding to another protein, PD-1, on immune cells. The binding of these “checkpoint” proteins suppresses the immune response[2]. Tecentriq (atezolizumab) is a monoclonal antibody that binds to PD-L1 and blocks its interactions with both PD-1 and B7.1 receptors[1]. By blocking this interaction, checkpoint inhibitors “release the brakes” on the immune system, allowing immune cells to attack tumours[2].
Is Tecentriq (atezolizumab) approved?
Tecentriq (atezolizumab) was approved by:
Food and Drugs Administration (FDA) (USA)
on May 18, 2016, for locally advanced or metastatic urothelial carcinoma, with disease progression on or after prior chemotherapy[2]. On April 17, 2017, the FDA extended the approval to the use of Tecentriq (atezolizumab) as front-line treatment for advanced or metastatic urothelial carcinoma in patients who are not eligible for cisplatin chemotherapy[4].
on October 18, 2016, for metastatic non-small cell lung cancer (NSCLC)[3].
Health Canada on April 12, 2017
for locally advanced or metastatic urothelial carcinoma, with disease progression on or after prior chemotherapy[8].
for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC) in combination with carboplatin and etoposide[8].
for the first-line treatment of adult patients with metastatic non-squamous non-small cell lung cancer (NSCLC) in combination with bevacizumab, paclitaxel and carboplatin[8].
for adult patients with locally advanced or metastatic NSCLC with progression on or after platinum-based chemotherapy[8].
Therapeutic Goods Administration (TGA) (AUS)
on July 27, 2017, for metastatic non-small cell lung cancer (NSCLC)[5].
European Medicines Agency (EMA) (EU)
on September 22, 2017, for locally advanced or metastatic non-small cell cancer (NSCLC) and metastatic urothelial carcinoma (mUC) on patients who have been previously treated with a platinum-based chemotherapy and as front-line treatment for advanced or metastatic urothelial carcinoma in patients who are not eligible for cisplatin chemotherapy[6].
on August 29, 2019, in combination with nab-paclitaxel for advanced TNBC in patients who have not been previously treated with chemotherapy for metastatic disease[10].
Medsafe on February 14, 2019
for first-line treatment of patients with metastatic non-squamous NSCLC who do not have tumour EGFR or ALK genomic aberrations[9].
for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy[9].
for the first-line treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC)[9].
for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma[9].
How do I take Tecentriq (atezolizumab)?
Complete information about Tecentriq (atezolizumab) dosage and administration can be found in the references section[1,5,7].
The recommended therapy consists of:
1200 mg as an intravenous infusion over 60 minutes every 3 weeks.
Dilute prior to intravenous infusion.
Complete information about Tecentriq (atezolizumab) dosage and administration can be found in the references section.
Consult your treating doctor for personalised dosing.
Are there any known side effects of Tecentriq (atezolizumab)?
The most common side effects (≥ 20%) in patients with locally advanced or metastatic urothelial carcinoma were fatigue, decreased appetite, nausea, constipation, urinary tract infection, diarrhea, and fever. The most common adverse reactions (≥ 20%) in patients with metastatic non-small cell lung cancer were fatigue, decreased appetite, dyspnea, cough, nausea, musculoskeletal pain, and constipation[1].
For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information[1,5,7].
References
1. Summary of Product Characteristics [FDA]: Tecentriq (atezolizumab) [PDF]
Genentech, Apr 2017.
2. National Cancer Institute. FDA approves new immunotherapy drug for bladder cancer
NIH
3. Approved Drugs: Atezolizumab (Tecentriq)
FDA, Oct 2016
4. FDA Grants Genentech’s Tecentriq (atezolizumab) Accelerated Approval as Initial Treatment for Certain People with Advanced Bladder Cancer
Drugs.com, April 2017
5. Summary of Product Characteristics [TGA]: Tecentriq (atezolizumab)
Roche, July 2017.
6. Roche receives EU approval of TECENTRIQ® (atezolizumab) in a specific type of metastatic lung cancer and two types of metastatic bladder cancer
Roche Media Release, Sept 2017.
7. Summary of Product Characteristics [EMA]: Tecentriq (atezolizumab) [PDF]
Roche, Jan 2018.
8. Summary of Product Characteristics [Health Canada]: Tecentriq (atezolizumab) [PDF]
Hoffmann-La Roche, Apr 2017.
9. Product detail [Medsafe]: Tecentriq (atezolizumab)
Hoffmann-La Roche, Mar 2020.
10. European Commission approves Roche’s Tecentriq in combination with Abraxane for people with PD-L1-positive, metastatic triple-negative breast cancer
Roche press release, Aug 2019.