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Tadalafil
Brand name: Cialis
Generic name: Tadalafil
Tadalafil Soft Pills are quick-dissolving tabs, used to treat male impotence.
Having the shortest start time of 15 minutes, Tadalafil Soft remains its most long-lasting effects of 36 hours among all the world-known ED products.
The neutral reaction to food or beverages makes Tadalafil Soft almost the best ED medication.
Tadalafil is in a class of medications known as PDE-5 inhibitors, which
are used to treat male impotence
Information about Tadalafil and how the tablets work and take
effect
Tadalafil acts in the same way as Viagra, by blocking an
enzyme called phosphodiesterase-5, or PDE-5. This helps the smooth muscles
in the penis relax and widen, which allows for more blood to enter. As a
result, you gain erections faster and easier with Tadalafil.Tadalafil is
a treatment for men with erectile dysfunction. This is when a man cannot
get, or can not keep a hard erect penis needed for sexual activity to please
his partner. Tadalafil does not work if there is no sexual stimulation.
You and your partner will need to engage in foreplay first as you would
naturally if you were not taking a medicine for erectile dysfunction.
How well does Tadalafil work ?
Tadalafil test results showed that out of 700 participants,
at least 88% of men experienced improvement with their erections and were
able to acheive erections from 12-24 hours after they take Tadalafil.
Tadalafil doseages
In Tadalafil clinical testing most men were administered one 10 mg Tadalafil
or 20 mg Tadalafil tablet per day.
Use in Adult Men
The recommended dose of Tadalafil is 20 mg, taken prior to anticipated
sexual activity. The maximum recommended dosing frequency is once per
day. Tadalafil may be taken between 30 minutes and 36 hours prior to anticipated
sexual activity. Patients may initiate sexual activity at varying time
points relative to dosing in order to determine their own optimal window
of responsiveness. The dose may be lowered to 10 mg based on individual
response and tolerability. Tadalafil may be taken without regard to food.
Use in Elderly Men
Tadalafil dosage adjustments are not required in elderly patients. Dosage
recommendations described in "Use in adult men" apply to elderly men.
Use in Men with Impaired Renal Function
Dosage adjustments are not required in patients with renal impairment.
Use in Men with Impaired Hepatic Function
Dosage adjustments are not required in patients with mild to moderate
hepatic impairment (Child-Pugh Class A and B) (see Pharmacokinetics).
Use in men with diabetes
The presence of diabetes does not require a dose reduction.
Use in children
Cialis should not be used in individuals below 18 years of age.
Side effects of Tadalafil
The most common side effects reported with Tadalafil in the study were
headache, myalgia (muscle pain), dyspepsia (upset stomach following meals)
and back pain. The severities of these Tadalafil side effects were minimized
with lower doses of Tadalafil.
Warnings and Precautions of Tadalafil
Sexual activity carries a potential cardiac risk for patients with pre-existing
cardiovascular disease. Therefore, treatments for erectile dysfunction,
including Tadalafil, should not be used in men with cardiac disease for
whom sexual activity is inadvisable. Physicians should consider the potential
cardiac risk of sexual activity in patients with pre-existing cardiovascular
disease.
Effects on Ability to Drive and Use Machines
Although the frequency of reports of dizziness in placebo and tadalafil
arms in clinical trials was similar, patients should be aware of how they
react to Tadalafil, before driving or operating machinery.
Adverse Effects of Tadalafil
Tadalafil was administered to over 4000 subjects (aged 19 to 86 years)
during clinical trials worldwide. Over 230 patients were treated for longer
than one year and over 720 patients were treated for over 6 months. In
controlled phase 2/3 clinical trials, the discontinuation rate due to
adverse effects in Tadalafil-treated patients (1.7%) was not significantly
different from placebo-treated patients (1.1%). In these studies, the
adverse effects reported with Tadalafil were generally mild or moderate,
transient, and decreased with continued dosing.
Overdosage of Tadalafil
Single doses of up to 500 mg of Tadalafil have been given to healthy subjects,
and multiple daily doses up to 100 mg have been given to patients. Adverse
events were similar to those seen at lower doses. In cases of an overdose
of Tadalafil, standard supportive measures should be adopted as required.
Storage of Tadalafil
Store below 25°C. Store in the original package.
Handling instructions on Tadalafil
No special requirements.
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