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Rosiglitazone

Brand names:Avandia

Generic name: Rosiglitazone Maleate

Rosiglitazone is used to hold down blood sugar levels in people with type 2 diabetes (also known as "non-insulin dependent" or "adult onset" diabetes). Blood sugar levels are ordinarily controlled by the body's natural supply of insulin, which helps sugar move out of the bloodstream and into the cells. In type 2 diabetes, the buildup of sugar in the blood is often due not to a lack of insulin, but to the body's inability to make proper use of it. Rosiglitazone works first by decreasing sugar production, then by helping the body make more efficient use of whatever insulin is available. It does not increase the actual amount of insulin in circulation. Rosiglitazone is a new type of diabetes medication. It can be used alone or in conjunction with insulin, metformin (Glucophage), or a member of the sulfonylurea class of diabetes drugs (Diabinese, Micronase, Orinase). It takes effect slowly. You may not see a reduction in blood sugar levels for the first 2 weeks of therapy, and it may take 2 to 3 months for Rosiglitazone to deliver maximum results

Most important fact about Rosiglitazone

Always remember that Rosiglitazone is an aid to, not a substitute for, good diet, weight loss, and exercise. Failure to follow a sound diet and exercise plan can lead to serious complications, such as dangerously high or low blood sugar levels. Remember, too, that Rosiglitazone is not an oral form of insulin, and cannot be used in place of insulin.

How should you take Rosiglitazone ?

Your dose of Rosiglitazone may be taken once a day in the morning or divided in half and taken in the morning and evening, with or without food.

If you miss a dose of Rosiglitazone

Take it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

Storage instructions for Rosiglitazone

Store at room temperature in a tight, light-resistant container.

What side effects when taking Rosiglitazone may occur ?

Side effects of Rosiglitazone cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Rosiglitazone.

More common side effects when taking Rosiglitazone may include:

Back pain, fatigue, headache, high blood sugar, low blood sugar, respiratory tract infections, sinus inflammation, swelling

Less common side effects when taking Rosiglitazone may include:

Anemia (low blood cell count), diarrhea

Rare side effects of taking Rosiglitazone may include:

Congestive heart failure

Why should Rosiglitazone not be prescribed ?

Do not take Rosiglitazone if it has ever given you an allergic reaction.

Special warnings about Rosiglitazone

If you have liver disease, you should not take Rosiglitazone. Your doctor will check to make sure your liver function is normal before prescribing Rosiglitazone, then recheck it every 2 months for the first 12 months and periodically thereafter. Warning signs of liver damage include nausea, vomiting, abdominal pain, fatigue, loss of appetite, and dark urine. If you develop any of these symptoms, tell your doctor immediately. You may need to discontinue treatment with Rosiglitazone.

People taking Rosiglitazone in combination with other diabetes drugs sometimes develop low blood sugar. If this happens, check with your doctor. The dosage of the other diabetes drug may have to be reduced.

People with kidney problems can take Rosiglitazone, but should not take Glucophage. If you have poor kidney function, you'll be unable to take advantage of this combination.

Rosiglitazone can increase the chances of conception. Be sure to use some form of birth control if you don't want a pregnancy.

Rosiglitazone won't help type 1 diabetics, who are unable to produce any insulin at all. Insulin shots are a necessity for this form of the illness. Nor can Rosiglitazone relieve diabetic ketoacidosis (excessively high sugar levels due to lack of insulin).

Use Rosiglitazone with caution if you have a problem with fluid retention or swelling. Rosiglitazone has been known to cause this problem, which in turn can lead to heart failure. Rosiglitazone should be avoided by anyone who has been diagnosed with heart failure, and it should be discontinued by anyone who develops it. Make sure the doctor is aware of any heart problems you may have. Alert him immediately if you develop symptoms of heart failure such as fatigue and shortness of breath.

You should be aware that people taking Rosiglitazone tend to gain a little weight, typically around 5 to 10 pounds. The cause is thought to be a combination of fluid retention and fat accumulation.

Rosiglitazone is not recommended for children under 18.

Possible food and drug interactions when taking Rosiglitazone

No drug interactions with Rosiglitazone have been reported at this time.

Special information if you are pregnant or breastfeeding

It's important to maintain normal blood sugar levels while pregnant, but the safety of Rosiglitazone during pregnancy remains unproven. Since insulin shots are known to be safe, your doctor may switch you from Rosiglitazone to insulin until the baby is born. It is not known whether Rosiglitazone appears in breast milk. Because many drugs do find their way into breast milk, however, the safest bet is to avoid taking Rosiglitazone while nursing.

Recommended dosages for Rosiglitazone

ADULTS

The usual starting dose of Rosiglitazone either alone or in combination with another diabetes drug is 4 milligrams once a day or 2 milligrams twice a day. If your sugar levels remain too high after 12 weeks of treatment, the doctor may increase your dose to 8 milligrams once a day or 4 milligrams twice a day. However, the maximum recommended dose of Rosiglitazone in combination with insulin or a sulfonylurea diabetes drug is 4 milligrams per day.

Overdosage with Rosiglitazone

Although there is no information on the potential results of Rosiglitazone overdose, any medication taken in excess can have serious consequences. If you suspect an overdose of Rosiglitazone, seek medical attention immediately.