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Risedronate

Generic name: Risedronate

Although our bones seem solid and stable, they actually undergo constant renewal. Specialized cells called osteoclasts draw used calcium out of the bones while other cells called osteoblasts replace it. Especially after menopause, this process can get out of balance. Calcium starts to leach out of the bones faster than it can be replaced, leading to the brittle-bone disease called osteoporosis. Risedronate combats this problem by reducing the activity of the osteoclasts and slowing the loss of calcium from the bones. Risedronate is prescribed for postmenopausal women, both to prevent osteoporosis and to strengthen the bones once the disease has begun. It is also used to prevent or treat osteoporosis resulting from therapy with steroid medications, and it is used in the treatment of Paget's disease, a condition in which patches of bone become softened and enlarged.

Both Risedronate and a similar drug called Fosamax are members of the family of drugs called bisphosphonates

Most important fact about Risedronate

Risedronate not only stops the bone loss of osteoporosis, but actually reverses the disease and increases bone mineral density. As the bones grow stronger, your chances of sustaining a fracture decline.

How should you take Risedronate ?

Two types of Risedronate are available: a 5-milligram tablet that's taken daily, and a 35-milligram tablet that's taken once a week. The Risedronate tablets should be taken at least 30 minutes before the first food or drink of the day other than water. Take the pill while standing or sitting in an upright position and wash it down with a full 6 to 8 ounce glass of plain water (do not use coffee, tea, juice, milk, or other dairy products). Swallow the tablet whole, do not chew or suck on it. Do not lie down for 30 minutes after taking Risedronate.

Other treatment measures typically include weight-bearing exercise, reduction of excessive smoking and drinking, and supplemental calcium and vitamin D if you don't get enough in your diet. If you require calcium supplements, or use any medications containing calcium, aluminum, or magnesium, avoid taking them at the same time of day as Risedronate.

If you miss a dose of Risedronate

If you realize that you missed a daily dose and have not yet had anything to eat or drink, it's okay to take your Risedronate. If you have already eaten, skip the dose for that day and take your regular dose the following morning.

If you forget to take a weekly dose, take 1 tablet on the morning after you remember, then return to taking 1 tablet a week as originally scheduled on the chosen day. Never take 2 tablets on the same day.

Storage instructions for Risedronate

Store at room temperature.

What side effects when taking Risedronate may occur ?

Side effects of Risedronate cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Risedronate.

More common side effects when taking Risedronate may include:

Abdominal pain, anxiety, back pain, belching, bladder irritation, bone disorders and pain, bronchitis, bursitis, cataracts, chest pain, colitis, constipation, depression, diarrhea, difficulty breathing, dizziness, dry eyes, eye infection, flu-like symptoms, gas, headache, high blood pressure, infection, insomnia, itching, joint disorders and pain, leg cramps, muscle pain, muscle weakness, nausea, neck pain, nerve pain, pain, pneumonia, rash, ringing in ears, sinus problems, sore throat, stomach bleeding, stuffy or runny nose, swelling, tendon problems, tumor, ulcers, urinary tract infection, vertigo, vision problems, weakness.

Less common side effects when taking Risedronate may include:

Why should Risedronate not be prescribed ?

Your doctor will not prescribe Risedronate if you have low calcium levels in your blood or Risedronate gives you an allergic reaction. You also cannot take Risedronate if you are unable to stand or sit upright for at least 30 minutes after taking Risedronate. In addition, Risedronate is not recommended for people with severe kidney disease.

Special warnings about Risedronate

The drugs in Risedronate's family have been known to cause problems in the canal between the mouth and the stomach (the esophagus). Among the disorders that have been reported are esophageal irritation, difficulty swallowing, esophageal ulcers, and gastric ulcers. You can guard against such problems by taking Risedronate with plenty of water, swallowing the pill while standing or sitting upright, and remaining upright for 30 minutes afterwards. If you experience difficulty or pain on swallowing, chest pain, or heartburn that is severe or worse than usual, stop taking Risedronate and check with your doctor immediately.

Possible food and drug interactions when taking Risedronate

If Risedronate is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

It is especially important to check with your doctor before combining Risedronate with the following:

Antacids
Calcium supplements
Laxatives such as Milk of Magnesia

Special information if you are pregnant or breastfeeding

Risedronate has caused harm when tested on pregnant animals. It is not recommended during human pregnancy unless its benefits are judged to outweigh the potential risks. If you are pregnant or plan to become pregnant, notify your doctor immediately. If you are nursing a baby, you'll need to choose between discontinuing nursing or discontinuing Risedronate.

Recommended dosages for Risedronate

ADULTS

Osteoporosis

For the prevention and treatment of osteoporosis, the recommended dose is one 5-milligram tablet of Risedronate once daily or one 35-milligram tablet once a week.

Steroid-Induced Osteoporosis

For treatment or prevention of steroid-induced osteoporosis, the recommended dose is one 5-milligram tablet once a day.

Paget's Disease

The recommended dose for Paget's disease is 30 milligrams once a day for two months. A second 2-month course of therapy may be required in certain individuals.

Overdosage with Risedronate

A large overdose of Risedronate can dramatically reduce calcium levels in the blood. Warning signs include a tingling sensation and spasms. If you suspect an overdose of Risedronate, seek medical attention immediately.