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Glipizide
Brand names: Minodiab, Glucotrol
Generic name: Glipizide

Glipizide is an oral antidiabetic medication used to treat
type 2 (non-insulin-dependent) diabetes. In diabetics either the body
does not make enough insulin or the insulin that is produced no longer
works properly.
There are actually two forms of diabetes: type 1 insulin-dependent
and type 2 non-insulin-dependent. Type 1 usually requires insulin injections
for life, while type 2 diabetes can usually be treated by dietary changes
and/or oral antidiabetic medications such as Glipizide. Apparently, Glipizide
controls diabetes by stimulating the pancreas to secrete more insulin.
Occasionally, type 2 diabetics must take insulin injections on a temporary
basis, especially during stressful periods or times of illness
Most important fact about Glipizide
Always remember that Glipizide is an aid to, not a substitute
for, good diet and exercise. Failure to follow a sound diet and exercise
plan can lead to serious complications, such as dangerously high or low
blood sugar levels. Remember, too, that Glipizide is not an oral form
of insulin, and cannot be used in place of insulin.
How should you take Glipizide ?
In general, to achieve the best control over blood sugar
levels, Glipizide should be taken 30 minutes before a meal. However, the
exact dosing schedule as well as the dosage amount must be determined
by your physician.
If you miss a dose of Glipizide
Take it as soon as you remember. If it is almost time
for your next dose, skip the one you missed and go back to your regular
schedule. Never take 2 doses at the same time.
Storage instructions for Glipizide
Glipizide should be stored at room temperature and protected
from moisture and humidity.
What side effects when taking Glipizide may occur
?
Side effects from Glipizide are rare and seldom require
discontinuation of Glipizide.
More common side effects when taking Glipizide
may include:
Constipation, diarrhea, dizziness, drowsiness, gas, headache,
hives, itching, low blood sugar, nervousness, sensitivity to light, skin
rash and eruptions, stomach pain, tremor.
Less common or rare side effects when taking Glipizide
may include:
Anemia and other blood disorders, yellow eyes and skin
Minodiab like all oral antidiabetic drugs, can cause low blood sugar.
This risk is increased by missed meals, alcohol, other diabetes medications,
and excessive exercise. Low blood sugar is also more likely in older people,
those with kidney or liver problems, and those with poorly functioning
adrenal or pituitary glands. To avoid low blood sugar, you should closely
follow the dietary and exercise regimen suggested by your physician.
Symptoms of mild low blood sugar may include:
Blurred vision, cold sweats, dizziness, fast heartbeat,
fatigue, headache, hunger, light-headedness, nausea, nervousness
Symptoms of more severe low blood sugar may include:
Coma, disorientation, pale skin, seizures, shallow breathing
Ask your doctor what steps you should take if you experience mild hypoglycemia.
If symptoms of severe low blood sugar occur, contact your doctor immediately.
Severe hypoglycemia should be considered a medical emergency, and prompt
medical attention is essential.
Why should Glipizide not be prescribed ?
You should not take Glipizide if you have had an allergic
reaction to it previously.
Glipizide will be stopped if you are suffering from diabetic
ketoacidosis (a life-threatening medical emergency caused by insufficient
insulin and marked by excessive thirst, nausea, fatigue, pain below the
breastbone, and a fruity breath).
Special warnings about Glipizide
It's possible that drugs such as Glipizide may lead to
more heart problems than diet treatment alone, or diet plus insulin. If
you have a heart condition, you may want to discuss this with your doctor.
If you are taking Glipizide, you should check your blood
and urine periodically for the presence of abnormal sugar (glucose) levels.
Even people with well-controlled diabetes may find that
injury, infection, surgery, or fever results in a lack of control over
their diabetes. In these cases, the physician may recommend that you stop
taking Glipizide temporarily and use insulin instead.
Glipizide may not work well in patients with poor kidney
or liver function.
In addition, the effectiveness of any oral antidiabetic,
including Glipizide, may decrease with time. This may occur because of
either a diminished responsiveness to Glipizide or a worsening of the
diabetes.
Possible food and drug interactions when taking
Glipizide
It is essential that you closely follow your physician's
dietary guidelines and that you inform your physician of any medication,
either prescription or nonprescription, that you are taking.
Specific medications that affect Glipizide include:
Airway-opening drugs such as Sudafed
Antacids such as Mylanta
Aspirin
Chloramphenicol (Chloromycetin)
Cimetidine (Tagamet)
Clofibrate (Atromid-S)
Corticosteroids such as prednisone (Deltasone)
Diuretics such as HydroDIURIL
Estrogens such as Premarin
Fluconazole (Diflucan)
Gemfibrozil (Lopid)
Heart and blood pressure medications called beta blockers such as Tenormin
and Lopressor
Heart medications called calcium channel blockers such as Cardizem and
Procardia XL
Isoniazid (Rifamate, Rimactane)
Itraconazole (Sporanox)
MAO inhibitors (antidepressant drugs such as Nardil and Parnate)
Major tranquilizers such as Thorazine and Mellaril
Miconazole (Monistat)
Nicotinic acid (Nicobid)
Nonsteroidal anti-inflammatory drugs such as Motrin and Naprosyn
Oral contraceptives
Phenytoin (Dilantin)
Probenecid (Benemid)
Rifampin (Rifadin)
Sulfa drugs such as Bactrim and Septra
Thyroid medications such as Synthroid
Warfarin (Coumadin)
Alcohol must be used carefully, since excessive alcohol
consumption can cause low blood sugar.
Special information if you are pregnant or breastfeeding
The effects of Glipizide during pregnancy have not been
adequately studied. Therefore, if you are pregnant, or planning to become
pregnant, you should take Glipizide only on the advice of your physician.
Since studies suggest the importance of maintaining normal blood sugar
(glucose) levels during pregnancy, your physician may prescribe insulin
during pregnancy. To minimize the risk of low blood sugar in newborn babies,
Glipizide, if taken during pregnancy, should be discontinued at least
one month before the expected delivery date. Although it is not known
if Glipizide appears in breast milk, other oral antidiabetics do. Because
of the potential for hypoglycemia in nursing infants, your doctor may
advise you either to discontinue Glipizide or to stop nursing. If Glipizide
is discontinued and if diet alone does not control glucose levels, your
doctor may prescribe insulin.
Recommended dosages for Glipizide
Dosage levels must be determined by each patient's needs.
ADULTS
The usual recommended starting dose of Glipizide is 5
milligrams taken before breakfast. Depending upon blood glucose response,
your doctor may increase the initial dose in increments of 2.5 to 5 milligrams.
The maximum recommended daily dose is 40 milligrams; total daily dosages
above 15 milligrams are usually divided into 2 equal doses that are taken
before meals.
CHILDREN
The safety and effectiveness of Glipizide in children
have not been established.
OLDER ADULTS
Older people or those with liver disease usually start
Glipizide therapy with 2.5 milligrams.
Overdosage with Glipizide
An overdose of Glipizide can cause low blood sugar. Eating
sugar or a sugar-based product will often correct the condition. Otherwise,
seek medical attention immediately.
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