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Donepezil
Other Brand
name: Aricept
Generic name: Donepezil hydrochloride

Donepezil is one of the few drugs that can provide some relief from
the symptoms of early Alzheimer's disease. (Cognex, Exelon, and Reminyl
are others.) Alzheimer's disease causes physical changes in the brain
that disrupt the flow of information and interfere with memory, thinking,
and behavior. Donepezil can temporarily improve brain function in some
Alzheimer's sufferers, although it does not halt the progress of the
underlying disease
Most important fact about Donepezil
To maintain any improvement, Donepezil must be taken regularly. If the
drug is stopped, its benefits will soon be lost. Patience is in order
when starting Donepezil. It can take up to 3 weeks for any positive
effects to appear.
How should you take Donepezil ?
Donepezil should be taken once a day just before bedtime. Be sure it's
taken every day. If Donepezil is not taken regularly, it won't work.
It can be taken with or without food.
If you miss a dose of Donepezil
Make it up as soon as you remember. If
it is almost time for the next dose, skip the one that was missed and
go back to the regular schedule. Never double the dose of Donepezil.
Storage instructions for Donepezil
Store at room temperature.
What side effects may occur taking
Donepezil ?
Side effects of Donepezil cannot be anticipated. If any develop or change
in intensity, tell the doctor as soon as possible. Only the doctor can
determine if it is safe to continue Donepezil.
Side effects of Donepezil are more likely
with higher doses. The most common are diarrhea, fatigue, insomnia,
loss of appetite, muscle cramps, nausea, and vomiting. When one of these
effects occurs, it is usually mild and gets better as treatment continues.
Other side effects of taking Donepezil
may include:
Abnormal dreams, arthritis, bruising, depression, dizziness, fainting,
frequent urination, headache, pain, sleepiness, weight loss
Why should Donepezil not be prescribed
?
There are two reasons to avoid Donepezil: an allergic reaction to the
drug itself, or an allergy to the group of antihistamines that includes
Claritin, Allegra, Atarax, Periactin, and Optimine.
Special warnings about Donepezil
Donepezil can aggravate asthma and other breathing problems, and can
increase the risk of seizures. It can also slow the heartbeat, cause
heartbeat irregularities, and lead to fainting episodes. Contact your
doctor if any of these problems occur.
In patients who have had stomach ulcers,
and those who take a nonsteroidal anti-inflammatory drug such as Advil,
Nuprin, or Aleve, Donepezil can make stomach side effects worse. Be
cautious when using Donepezil and report all side effects to your doctor.
Possible food and drug interactions
when taking Donepezil
Donepezil will increase the effects of certain anesthetics. Make sure
the doctor is aware of Donepezil therapy prior to any surgery.
If Donepezil is taken with certain other
drugs, the effects of either could be increased, decreased, or altered.
It is especially important to check
with your doctor before combining Donepezil with the following:
Antispasmodic drugs such as Bentyl, Cogentin,
and Pro-Banthine
Bethanechol chloride (Urecholine)
Carbamazepine (Tegretol)
Dexamethasone (Decadron)
Ketoconazole (Nizoral)
Phenobarbital
Phenytoin (Dilantin)
Quinidine (Quinidex)
Rifampin (Rifadin, Rifamate)
Special information if you are
pregnant or breastfeeding
Since it is not intended for women of child-bearing age, Donepezil 's
effects during pregnancy have not been studied, and it is not known
whether it appears in breast milk.
Recommended dosages for Donepezil
ADULTS
The usual starting dose is 5 milligrams
once a day at bedtime for at least 4 to 6 weeks. Do not increase the
dose during this period unless directed. The doctor may then change
the dosage to 10 milligrams once a day if response to the drug warrants
it.
CHILDREN
The safety and effectiveness of Donepezil
has not been established in children.
Overdosage of Donepezil
Any medication taken in excess can have serious consequences. If you
suspect an overdose of Donepezil, seek medical attention immediately.
Symptoms of Donepezil overdose
include:
Collapse, convulsions, extreme muscle weakness (possibly ending in death
if breathing muscles are affected), low blood pressure, nausea, salivation,
slowed heart rate, sweating, vomiting
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